Glomerular fine structure in mixed membranous and proliferative glomerulonephritis

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Glomerular fine structure in mixed membranous and proliferative glomerulonephritis.

A case of mixed membranous and proliferative glomerulonephritis has been studied by light and electron microscopy. Electron microscopy has shown that the cellular proliferation is mesangial in origin and that there are qualitative and quantitative alterations in the filtration basement membrane. In addition there are numerous examples of direct contact between filtration basement membrane and n...

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BACKGROUND/AIMS Immunologically and hemodynamically mediated the destruction of glomerular architecture is thought to be the major causes of end-stage renal failure. The purpose of this study is to evaluate the effect of glomerular hypertension on glomerular injury and the progression of glomerular sclerosis after Thy-1 nephritis was induced. METHOD Thy-1 nephritis was induced in the stroke-p...

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Abnormal expression of glomerular basement membrane laminins in membranous glomerulonephritis.

BACKGROUND Proteinuria associated with glomerular diseases is secondary to alterations of the charge-selective and/or size-selective properties of the glomerular basement membrane (GBM), but molecular alterations that are responsible for these functional changes are still poorly understood. Analysis of mice harbouring a null mutation in the gene encoding the beta 2 chain of laminin has suggeste...

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Mesangial cells in membranous glomerulonephritis.

Renal biopsies of seven patients with membranous glomerulonephritis were examined by light, electron, and immunofluorescence microscopy. All had characteristic changes of glomerular basement membranes, typically with bright granular membranous fluorescence of IgG and variable deposits of complement. Cellularity was normal or slightly increased due largely to mesangial cell proliferation. These ...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1970

ISSN: 0021-9746

DOI: 10.1136/jcp.23.7.613